Kolexia
Moullier Philippe
Médecine générale
CHU Nantes
Nantes, France
84 Activités
2 Followers

Scientifique
Digital
Production scientifique
Activités par an
Expertise
Sujets de recherche
{{person.topmesh1.name}} Myopathie de Duchenne Dystrophies musculaires Myopathies congénitales structurales Maladies musculaires Amaurose congénitale de Leber Leucodystrophie métachromatique Dégénérescence de la rétine Dystrophies des cônes et des batonnets Rétinite pigmentaire

Industries

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Dernières activités

Mannose-coupled AAV2: A second-generation AAV vector for increased retinal gene therapy efficiency.
Molecular therapy. Methods & clinical development   17 janvier 2024
Evaluation of an AAV9-mini-dystrophin gene therapy candidate in a rat model of Duchenne muscular dystrophy.
Molecular therapy. Methods & clinical development   18 mai 2023
Cellular and Structural Characterization of VP1 and VP2 Knockout Mutants of AAV3B Serotype and Implications for AAV Manufacturing.
Human gene therapy   16 novembre 2022
Evaluation of the dystrophin carboxy-terminal domain for micro-dystrophin gene therapy in cardiac and skeletal muscles in the DMD rat model.
Gene therapy   01 février 2022
TG-MLD: A Phase I/II, Open Labeled, Monocentric Study of Direct Intracranial Administration of a Replication Deficient Adeno-associated Virus Gene Transfer Vector Serotype rh.10 Expressing the Human ARSA cDNA to Children With Metachromatic Leukodystrophy.
Essai Clinique (Institut National de la Santé Et de la Recherche Médicale, France)   10 janvier 2022
AAV8 locoregional delivery induces long-term expression of an immunogenic transgene in macaques despite persisting local inflammation.
Molecular therapy. Methods & clinical development   06 février 2021
Intra-CSF AAV9 and AAVrh10 Administration in Nonhuman Primates: Promising Routes and Vectors for Which Neurological Diseases?
Molecular therapy. Methods & clinical development   11 avril 2020
Capsid-specific removal of circulating antibodies to adeno-associated virus vectors.
Scientific reports   21 janvier 2020
Tetramer-Based Enrichment of Preexisting Anti-AAV8 CD8 T Cells in Human Donors Allows the Detection of a T Subpopulation.
Frontiers in immunology   21 janvier 2020
Non-Ambulant Duchenne Patients Theoretically Treatable by Exon 53 Skipping have Severe Phenotype.
Journal of neuromuscular diseases   20 novembre 2019